
The Cultured Biomecare Biome-One Serum is skincare stripped back to its essence, yet it somehow delivers more than you’d expect. Designed to rebalance the skin’s microbiome, it targets dullness, dehydration, sensitivity, and even breakouts with a simple yet effective formula that prioritises skin health above all else.
What is it?
A hydrating serum that helps promote radiance and fortify the skin barrier.
What Do I Think?
The serum has a silky, milky texture that glides effortlessly onto the skin, immediately soothing and hydrating without any heaviness or stickiness. Packed with probiotics, fermented hyaluronic acid, black tea, microalgae, and inulin, it works to optimise skin function, repair the barrier, and deliver deep hydration. The results? Calm, less reactive skin, improved redness, a supple texture, and an overall healthier appearance.
One of my favourite things about this serum is the glowing, glass-skin finish it gives. It’s a comfort blanket for dry, irritated skin, offering essential hydration that plumps fine dehydration lines and smooths the surface. I’ve also found it invaluable for layering under stronger actives, like retinoids, to keep my barrier resilient and happy.
I’d confidently recommend this to all skin types. If, like me, you’re on the drier side, it’s a wonderful product to layer under your moisturiser. If you’re oilier, it may even give you enough hydration to skip moisturiser altogether and head straight to SPF.

Would I recommend?
Thoughtful, effective, and beautifully simple, this is a serum that truly delivers on its promise of calm, balanced skin. It’s a brilliant addition to any routine, whether you’re focused on repair, hydration, or simply maintaining healthy skin.
Brands Product Description
Cultured Biomecare Biome One Serum has a weightless, silky texture that absorbs in an instant. It’s powered by Super Ferments and actives – new-era actives that relaunch the skin’s natural power of self-regeneration and renewal. Fermented Hyaluronic Acid and prebiotic Inulin flood the skin with hydration, fortifying the skin barrier and microbiome. It also contains an antioxidant complex, which delivers potent cellular defence. Skin is left protected, strengthened and at its visibly healthiest, ageless best.
Key Ingredients
- Fermented Micro-algae – Promotes cell regeneration, microbiome support
- Fermented Lactococcus Lactis – Optimised skin function and renewal
- Fermented Black Tea – Improves skin radiance
- Fermented Hyaluronic Acid – Intense hydration
- Prebiotic Inulin – Deep skin hydration & skin barrier health


How I Use It
I use this morning and evening after Vitamin C or my retinoid, and before moisturiser.
Would I Repurchase/Buy?
Yes!
How Much?
£55.00 for 60ml. It’s important to note that this is a whopping 60ml. Typically serums are a 30ml, so you’re getting double the amount of serum, hence the higher price point.